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TRAP Antibody

CAT: 0223-6911-01Size: 0.02 mgDry Ice: NoHazardous: No
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CAT#:0223-6911-01Size:0.02 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
TRAP Antibody: TRAP, also known as uteroferrin, is an iron containing, glycosylated, acid phosphatase. It is the most basic of the acid phosphatases and is the only form not inhibited by L (+) -tartrate. Along with the related protein ACP2, TRAP mediates the removal of mannose 6-phosphate residues from proteins targeted to lysosomes. TRAP is present in brain at low levels, but is expressed at a much higher level in liver.
NCBI Gene ID
54
Swiss Prot
P13686
Accession Number
NP_001104505
Host
Rabbit
Reactivity
Human, Mouse
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Homeostasis
Purification
TRAP Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1403 - Mouse Brain Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Pig: (94%), Rat: (89%), Rabbit: (88%)
Buffer
TRAP Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
TRAP antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Symbol
ACP5
Positive Control 2
Cat. No. 10-201 - Human Liver Tissue Slide
NCBI Official Name
Acid phosphatase 5, tartrate resistant
NCBI Organism
Homo sapiens
Background Reference 01
Baumbach GA, Saunders PT, Bazer FW, et al. Uteroferrin has N-apsaragine-linked high mannose-type oligosaccharaides that contain mannose 6-phosphate. Proc. Natl. Acad. Sci. USA 1984; 81:2985-9.
Background Reference 02
Sun P, Sleat DE, Lecocq M, et al. Acid phosphatase 5 is responsible for removing the mannose 6-phosphate recognition marker from lysosomal proteins. Proc. Natl. Acad. Sci. USA 2004; 105:16590-5.
Background Reference 03
Makypridi G, Damme M, Muller-Loennies S, et al. Mannose 6 dephosphorylation of lysosomal proteins mediated by acid phosphatases Acp2 and Acp5. Mol. Cell Biol. 2012; 32:774-82.
Other Product Names
TRAP Antibody: TRAP, SPENCDI, Tartrate-resistant acid phosphatase type 5, Tartrate-resistant acid ATPase, TR-AP
Tested Applications
ELISA, WB, IF
Protein ID
161377453
Physical Properties
Liquid

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