TRAF1 Antibody

CAT: 0223-57-370Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-57-370Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV) . EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors. Three transcript variants encoding two different isoforms have been found for this gene.
NCBI Gene ID
7185
Swiss Prot
Q13077
Accession Number
Q13077
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This TRAF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 55-83 amino acids from the N-terminal region of human TRAF1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
46 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
TRAF1
NCBI Official Name
TNF receptor-associated factor 1
NCBI Organism
Homo sapiens
Background Reference 01
Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)
Background Reference 02
Plant, D., et al. Ann. Rheum. Dis. 69 (8) :1548-1553 (2010)
Background Reference 03
Stahl, E.A., et al. Nat. Genet. 42 (6) :508-514 (2010)
Background Reference 04
Tan, R.J., et al. Ann. Rheum. Dis. 69 (6) :1029-1035 (2010)
Other Product Names
TNF receptor-associated factor 1, Epstein-Barr virus-induced protein 6, TRAF1, EBI6
Tested Applications
WB
Protein ID
6707734
Physical Properties
Liquid

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