TRAF1 Antibody

• Background:

  The protein encoded by this gene is a member of the TNF receptor (TNFR) associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from various receptors of the TNFR superfamily. This protein and TRAF2 form a heterodimeric complex, which is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF2 also interacts with inhibitor-of-apoptosis proteins (IAPs), and thus mediates the anti-apoptotic signals from TNF receptors. The expression of this protein can be induced by Epstein-Barr virus (EBV) . EBV infection membrane protein 1 (LMP1) is found to interact with this and other TRAF proteins; this interaction is thought to link LMP1-mediated B lymphocyte transformation to the signal transduction from TNFR family receptors. Three transcript variants encoding two different isoforms have been found for this gene.

• NCBI Gene ID:

  7185

• Swiss Prot:

  Q13077

• Accession Number:

  Q13077

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This TRAF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 55-83 amino acids from the N-terminal region of human TRAF1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  46 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  TRAF1

• NCBI Official Name:

  TNF receptor-associated factor 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

• Background Reference 02:

  Plant, D., et al. Ann. Rheum. Dis. 69 (8) :1548-1553 (2010)

• Background Reference 03:

  Stahl, E.A., et al. Nat. Genet. 42 (6) :508-514 (2010)

• Background Reference 04:

  Tan, R.J., et al. Ann. Rheum. Dis. 69 (6) :1029-1035 (2010)

• Other Product Names:

  TNF receptor-associated factor 1, Epstein-Barr virus-induced protein 6, TRAF1, EBI6

• Tested Applications:

  WB

• Protein ID:

  6707734

• Physical Properties:

  Liquid