CFL2 Antibody

• Background:

  This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants.

• NCBI Gene ID:

  1073

• Swiss Prot:

  Q9Y281

• Accession Number:

  Q9Y281

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CFL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25-54 amino acids from the N-terminal region of human CFL2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Pig

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  19 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  CFL2

• NCBI Official Name:

  Cofilin-2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Vogel, S., et al. J. Biol. Chem. 285 (44) :33756-33763 (2010) Borensztajn, K., et al. Thromb. Res. 125 (6), E323-E328 (2010) Papalouka, V., et al. Mol. Cell. Biol. 29 (22) :6046-6058 (2009) Wu, Y., et al. Retrovirology 5, 95 (2008) Agrawal, P.B., et al. Am. J. Hum. Genet. 80 (1) :162-167 (2007)

• Other Product Names:

  Cofilin-2, Cofilin, muscle isoform, CFL2

• Tested Applications:

  WB, IHC-P

• Protein ID:

  6831517

• Physical Properties:

  Liquid