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RFX5 Antibody

CAT: 0223-57-412Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-412Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
A lack of MHC-II expression results in a severe immunodeficiency syndrome called MHC-II deficiency, or the bare lymphocyte syndrome (BLS; MIM 209920) . At least 4 complementation groups have been identified in B-cell lines established from patients with BLS. The molecular defects in complementation groups B, C, and D all lead to a deficiency in RFX, a nuclear protein complex that binds to the X box of MHC-II promoters. The lack of RFX binding activity in complementation group C results from mutations in the RFX5 gene encoding the 75-kD subunit of RFX (Steimle et al., 1995) . RFX5 is the fifth member of the growing family of DNA-binding proteins sharing a novel and highly characteristic DNA-binding domain called the RFX motif. Multiple alternatively spliced transcript variants have been found but the full-length natures of only two have been determined. [provided by RefSeq].
NCBI Gene ID
5993
Swiss Prot
P48382
Accession Number
P48382
Host
Rabbit
Reactivity
Human
Immunogen
This RFX5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 237-266 amino acids from the Central region of human RFX5.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
65 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
RFX5
NCBI Official Name
DNA-binding protein RFX5
NCBI Organism
Homo sapiens
Background Reference 01
Laird, K.M., et al. J. Mol. Biol. 403 (1) :40-51 (2010)
Background Reference 02
Kong, X., et al. J. Mol. Cell. Cardiol. 46 (3) :292-299 (2009)
Background Reference 03
Garvie, C.W., et al. Biochim. Biophys. Acta 1779 (12) :797-804 (2008)
Background Reference 04
Ennis, S., et al. Lancet 372 (9652) :1828-1834 (2008)
Other Product Names
DNA-binding protein RFX5, Regulatory factor X 5, RFX5
Tested Applications
WB
Protein ID
1350587
Physical Properties
Liquid

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