Products for Research Use Only
RegisterLogin

RFX1 Antibody

CAT: 0223-8199-01Size: 0.02 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-8199-01Size:0.02 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
RFX1 is a member of the regulatory factor X protein family, which are transcription factors that contain a highly-conserved winged helix DNA binding domain and the D region found in the C-terminal part of these proteins which facilitates dimerization (1,2) . RFX1 is structurally related to regulatory factors X2, X3, X4, and X5 (3) . RFX1 is a regulatory factor essential for MHC class II genes expression and can bind to an inverted repeat that is required for expression of hepatitis B virus genes (4) . Recent study identifies RFX1 may play a tumor suppressor role in HCC as autophagy mediator (5) .
NCBI Gene ID
5989
Swiss Prot
P22670
Accession Number
NP_002909
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology, Autophagy
Purification
RFX1 antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1201 - HeLa Cell Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Mouse: (89%)
Buffer
RFX1 antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
RFX1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.
Observed Molecular Weight
Multiple independent RFX1 antibodies also show a band at ~130 kDa
Fragment
IgG
Specificity
RFX1 antibody is human specific. At least two isoforms of RFX1 are known to exist; this antibody will detect both isoforms.
Symbol
RFX1
Positive Control 2
Cat. No. 17-001 - HeLa Cell Slide
NCBI Official Name
Regulatory factor X, 1 (influences HLA class II expression)
NCBI Organism
Homo sapiens
Background Reference 01
Reith W, Ucla C, Barras E, et al. RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins. Mol. Cell Biol. 1994; 14:1230-44.
Background Reference 02
Katan-Khaykovich Y and Shaul Y. RFX1, a single DNA-binding protein with a split dimerization domain, generates alternative complexes. J. Biol. Chem. 1998; 273:24504-12.
Background Reference 03
Hsu YC, Liao WC, Kao CY, et al. Regulation of FGF1 gene promoter through transcription factor RFX1. J. Biol. Chem. 2010; 285:13885-95.
Background Reference 04
Su JC, Tseng PH, Hsu CY, et al. RFX1-dependent activation of SHP-1 induces autophagy by a novel obatoclax derivative in hepatocellular carcinoma cells. Oncotarget 2014; 5:4909-19.
Other Product Names
RFX, MHC class II regulatory factor RFX, MHC class II regulatory factor RFX1, enhancer factor C, EFC, trans-acting regulatory factor 1, transcription factor RFX1
Tested Applications
ELISA, WB, ICC, IF
Protein ID
238859557
Physical Properties
Liquid

Related Products

CatalogName
8199PRFX1 Peptide
29-107RFX4 Antibody
28-766RFX5 Antibody
28-765RFX5 Antibody
43-250RFX5 Antibody
25-404RFX2 Antibody
56-549RFX3 Antibody
57-412RFX5 Antibody
29-184RFX4 Antibody
56-666RFX2 Antibody

Alternative Products

CatalogName
DF15965-01RFX1 Antibody
MBS9432837-01RFX1 Polyclonal Antibody
GTR17895873-01RFX1 Antibody (Biotin)
MBS8307924-01Anti-RFX1 Antibody
574631-01RFX1

Popular Products