Mouse Map3k7 Antibody

• Background :

  Component of a protein kinase signal transduction cascade. Mediator of TRAF6 and TGF-beta signal transduction. Activates IKBKB and MAPK8 in response to TRAF6 signaling. Stimulates NF-kappa-B activation and the p38 MAPK pathway. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK, but not that of NF-kappa-B.

• NCBI Gene ID :

  26409

• Swiss Prot :

  Q62073

• Accession Number :

  Q62073

• Host :

  Rabbit

• Reactivity :

  Human, Mouse

• Immunogen :

  This Mouse Map3k7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 131-160 amino acids from the N-terminal region of mouse Map3k7.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cancer, Immunology, Signal Transduction

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Homology :

  Predicted species reactivity based on immunogen sequence: Bovine, Rat

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  64 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  Map3k7

• NCBI Official Name :

  Mitogen-activated protein kinase kinase kinase 7

• NCBI Organism :

  Mus musculus

• Background Reference 01 :

  Kajino-Sakamoto, R., et al. J. Immunol. 185 (8) :4729-4737 (2010)

• Background Reference 02 :

  Wu, Z.H., et al. Mol. Cell 40 (1) :75-86 (2010)

• Background Reference 03 :

  Scholz, R., et al. J. Biol. Chem. 285 (33) :25753-25766 (2010)

• Background Reference 04 :

  Greenblatt, M.B., et al. J. Clin. Invest. 120 (7) :2457-2473 (2010)

• Other Product Names :

  Mitogen-activated protein kinase kinase kinase 7, Transforming growth factor-beta-activated kinase 1, TGF-beta-activated kinase 1, Map3k7, Tak1

• Tested Applications :

  WB, IHC-P

• Physical Properties :

  Liquid