Mouse Map3k7 Antibody

• Background:

  Component of a protein kinase signal transduction cascade. Mediator of TRAF6 and TGF-beta signal transduction. Activates IKBKB and MAPK8 in response to TRAF6 signaling. Stimulates NF-kappa-B activation and the p38 MAPK pathway. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK, but not that of NF-kappa-B.

• NCBI Gene ID:

  26409

• Swiss Prot:

  Q62073

• Accession Number:

  Q62073

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This Mouse Map3k7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 131-160 amino acids from the N-terminal region of mouse Map3k7.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Immunology, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Bovine, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  64 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  Map3k7

• NCBI Official Name:

  Mitogen-activated protein kinase kinase kinase 7

• NCBI Organism:

  Mus musculus

• Background Reference 01:

  Kajino-Sakamoto, R., et al. J. Immunol. 185 (8) :4729-4737 (2010)

• Background Reference 02:

  Wu, Z.H., et al. Mol. Cell 40 (1) :75-86 (2010)

• Background Reference 03:

  Scholz, R., et al. J. Biol. Chem. 285 (33) :25753-25766 (2010)

• Background Reference 04:

  Greenblatt, M.B., et al. J. Clin. Invest. 120 (7) :2457-2473 (2010)

• Other Product Names:

  Mitogen-activated protein kinase kinase kinase 7, Transforming growth factor-beta-activated kinase 1, TGF-beta-activated kinase 1, Map3k7, Tak1

• Tested Applications:

  WB, IHC-P

• Physical Properties:

  Liquid