PTF1A Antibody

• Background:

  This gene encodes a protein that is a component of the pancreas transcription factor 1 complex (PTF1) and is known to have a role in mammalian pancreatic development. The protein plays a role in determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. The protein is thought to be involved in the maintenance of exocrine pancreas-specific gene expression including elastase 1 and amylase. Mutations in this gene cause cerebellar agenesis and loss of expression is seen in ductal type pancreas cancers.

• NCBI Gene ID:

  256297

• Swiss Prot:

  Q7RTS3

• Accession Number:

  Q7RTS3

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This PTF1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 287-316 amino acids from the C-terminal region of human PTF1A.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  35 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  PTF1A

• NCBI Official Name:

  Pancreas transcription factor 1 subunit alpha

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Meredith, D.M., et al. J. Neurosci. 29 (36) :11139-11148 (2009)

• Background Reference 02:

  Rodolosse, A., et al. Biochem. J. 418 (2) :463-473 (2009)

• Background Reference 03:

  Tutak, E., et al. Genet. Couns. 20 (2) :147-152 (2009)

• Background Reference 04:

  Yamada, M., et al. J. Neurosci. 27 (41) :10924-10934 (2007)

• Other Product Names:

  Pancreas transcription factor 1 subunit alpha, Class A basic helix-loop-helix protein 29, bHLHa29, Pancreas-specific transcription factor 1a, bHLH transcription factor p48, p48 DNA-binding subunit of transcription factor PTF1, PTF1-p48, PTF1A, BHLHA29, PTF1P48

• Tested Applications:

  WB

• Protein ID:

  74749931

• Physical Properties:

  Liquid