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CENPA Antibody

CAT: 0223-57-304Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-304Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4) 2 tetrameric core of the nucleosome particle. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq].
NCBI Gene ID
1058
Swiss Prot
P49450
Accession Number
P49450
Host
Rabbit
Reactivity
Human
Immunogen
This CENPA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 82-110 amino acids from the Central region of human CENPA.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine, Hamster
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
16 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
CENPA
NCBI Official Name
Histone H3-like centromeric protein A
NCBI Organism
Homo sapiens
Background Reference 01
Sekulic, N., et al. Nature 467 (7313) :347-351 (2010)
Background Reference 02
Carroll, C.W., et al. J. Cell Biol. 189 (7) :1143-1155 (2010)
Background Reference 03
Maehara, K., et al. Mol. Cell. Biol. 30 (9) :2090-2104 (2010)
Background Reference 04
Buscaino, A., et al. Curr. Opin. Genet. Dev. 20 (2) :118-126 (2010)
Other Product Names
Histone H3-like centromeric protein A, Centromere autoantigen A, Centromere protein A, CENP-A, CENPA
Tested Applications
WB
Protein ID
1345726
Physical Properties
Liquid

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