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CENPB Antibody

CAT: 0223-16-761Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0223-16-761Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies.
NCBI Gene ID
1059
Swiss Prot
P07199
Host
Rabbit
Reactivity
Mouse, Rat
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 500 to the C-terminus of human CENPB (NP_001801.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
Affinity purification
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Fragment
IgG
Applications Notes
WB: 1:500 - 1:2000
Symbol
CENPB
NCBI Official Name
Centromere protein B
NCBI Organism
Homo sapiens
Other Product Names
Major centromere autoantigen B, CENP-B, centromere autoantigen B, centromere protein B, 80kDa
Tested Applications
WB
Physical Properties
Liquid

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