CENPP Antibody

• Background:

  CENPP is the component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. CENPP may be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.CENPP is a subunit of a CENPH (MIM 605607) -CENPI (MIM 300065) -associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]) .

• NCBI Gene ID:

  401541

• Swiss Prot:

  Q6IPU0

• Accession Number:

  NP_001012267

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human CENPP.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  Antibody is purified by peptide affinity chromatography method.

• Positive Control:

  Tranfected 293T Cell Lysate

• Concentration:

  Batch dependent

• Buffer:

  Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  For short periods of storage (days) store at 4˚ C. For longer periods of storage, store CENPP antibody at -20˚ C. As with any antibody avoid repeat freeze-thaw cycles.

• Calculated Molecular Weight:

  33 kDa

• Applications Notes:

  CENPP antibody can be used for detection of CENPP by ELISA at 1:312500. CENPP antibody can be used for detection of CENPP by western blot at 1 μ g/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.

• Symbol:

  CENPP

• NCBI Official Name:

  Centromere protein P

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Okada, M., (2006) Nat. Cell Biol. 8 (5), 446-457.

• Other Product Names:

  CENPP, CENP-P, FLJ33928, RP11-19J3.3

• Tested Applications:

  ELISA, WB

• Protein ID:

  59709758

• Physical Properties:

  Liquid