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CELA3B Antibody

CAT: 0223-57-258Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-258Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays.
NCBI Gene ID
23436
Swiss Prot
P08861
Accession Number
P08861
Host
Rabbit
Reactivity
Human
Immunogen
This CELA3B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 70-98 amino acids from the N-terminal region of human CELA3B.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
29 kDa
Fragment
Rabbit Ig
Symbol
CELA3B
NCBI Official Name
Chymotrypsin-like elastase family member 3B
NCBI Organism
Homo sapiens
Background Reference 01
Gao, J., et al. Oncol. Rep. 23 (6) :1683-1692 (2010)
Background Reference 02
Teichmann, J., et al. Eur. J. Med. Res. 13 (12) :563-567 (2008)
Background Reference 03
Hahn, J.U., et al. Pancreas 36 (3) :274-278 (2008)
Background Reference 04
Mann, S.T., et al. Eur. J. Med. Res. 13 (2) :68-72 (2008)
Other Product Names
Chymotrypsin-like elastase family member 3B, Elastase IIIB, Elastase-3B, Protease E, CELA3B, ELA3B
Tested Applications
WB, IHC-P
Protein ID
317373457
Physical Properties
Liquid

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