CELA3B Antibody

• Background:

  Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays.

• NCBI Gene ID:

  23436

• Swiss Prot:

  P08861

• Accession Number:

  P08861

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This CELA3B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 70-98 amino acids from the N-terminal region of human CELA3B.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  29 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  CELA3B

• NCBI Official Name:

  Chymotrypsin-like elastase family member 3B

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Gao, J., et al. Oncol. Rep. 23 (6) :1683-1692 (2010)

• Background Reference 02:

  Teichmann, J., et al. Eur. J. Med. Res. 13 (12) :563-567 (2008)

• Background Reference 03:

  Hahn, J.U., et al. Pancreas 36 (3) :274-278 (2008)

• Background Reference 04:

  Mann, S.T., et al. Eur. J. Med. Res. 13 (2) :68-72 (2008)

• Other Product Names:

  Chymotrypsin-like elastase family member 3B, Elastase IIIB, Elastase-3B, Protease E, CELA3B, ELA3B

• Tested Applications:

  WB, IHC-P

• Protein ID:

  317373457

• Physical Properties:

  Liquid