MMP19 Antibody

• Background:

  Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This protein is expressed in human epidermis and it has a role in cellular proliferation as well as migration and adhesion to type I collagen. Multiple transcript variants encoding distict isoforms have been identified for this gene.

• NCBI Gene ID:

  4327

• Swiss Prot:

  Q99542

• Accession Number:

  Q99542

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This MMP19 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 55-84 amino acids from the N-terminal region of human MMP19.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  57 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  MMP19

• NCBI Official Name:

  Matrix metalloproteinase-19

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :

• Background Reference 02:

  Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

• Background Reference 03:

  Romero, R., et al. Am. J. Obstet. Gynecol. 202 (5), 431 (2010) :

• Background Reference 04:

  Muller, M., et al. Mod. Pathol. 23 (4) :511-521 (2010)

• Other Product Names:

  Matrix metalloproteinase-19, MMP-19, 3424-, Matrix metalloproteinase RASI, Matrix metalloproteinase-18, MMP-18, MMP19, MMP18, RASI

• Tested Applications:

  WB

• Protein ID:

  12643345

• Physical Properties:

  Liquid