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MMP17 Antibody

CAT: 0223-62-174Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-62-174Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP17 is considered a member of the membrane-type MMP (MT-MMP) subfamily. However, this protein is unique among the MT-MMPs in that it is a GPI-anchored protein rather than a transmembrane protein. The protein activates MMP-2 by cleavage.
NCBI Gene ID
4326
Swiss Prot
Q9ULZ9
Accession Number
Q9ULZ9
Host
Rabbit
Reactivity
Human
Immunogen
This MMP17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 391-420 amino acids from the Central region of human MMP17.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
67 kDa
Fragment
Rabbit Ig
Symbol
MMP17
NCBI Official Name
Matrix metalloproteinase-17
NCBI Organism
Homo sapiens
Background Reference 01
Jung, M., et al., Prostate 55 (2) :89-98 (2003) .
Background Reference 02
Itoh, Y., et al., J. Biol. Chem. 274 (48) :34260-34266 (1999) .
Background Reference 03
Wang, Y., et al., J. Biol. Chem. 274 (46) :33043-33049 (1999) .
Background Reference 04
Kajita, M., et al., FEBS Lett. 457 (3) :353-356 (1999) .
Other Product Names
Matrix metalloproteinase-17, MMP-17, 3424-, Membrane-type matrix metalloproteinase 4, MT-MMP 4, MTMMP4, Membrane-type-4 matrix metalloproteinase, MT4-MMP, MT4MMP, MMP17, MT4MMP
Tested Applications
WB, IHC-P
Protein ID
296439485
Physical Properties
Liquid

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