MMP17 Antibody

• Background:

  Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP17 is considered a member of the membrane-type MMP (MT-MMP) subfamily. However, this protein is unique among the MT-MMPs in that it is a GPI-anchored protein rather than a transmembrane protein. The protein activates MMP-2 by cleavage.

• NCBI Gene ID:

  4326

• Swiss Prot:

  Q9ULZ9

• Accession Number:

  Q9ULZ9

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This MMP17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 391-420 amino acids from the Central region of human MMP17.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Signal Transduction

• Purification:

  This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  67 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  MMP17

• NCBI Official Name:

  Matrix metalloproteinase-17

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Jung, M., et al., Prostate 55 (2) :89-98 (2003) .

• Background Reference 02:

  Itoh, Y., et al., J. Biol. Chem. 274 (48) :34260-34266 (1999) .

• Background Reference 03:

  Wang, Y., et al., J. Biol. Chem. 274 (46) :33043-33049 (1999) .

• Background Reference 04:

  Kajita, M., et al., FEBS Lett. 457 (3) :353-356 (1999) .

• Other Product Names:

  Matrix metalloproteinase-17, MMP-17, 3424-, Membrane-type matrix metalloproteinase 4, MT-MMP 4, MTMMP4, Membrane-type-4 matrix metalloproteinase, MT4-MMP, MT4MMP, MMP17, MT4MMP

• Tested Applications:

  WB, IHC-P

• Protein ID:

  296439485

• Physical Properties:

  Liquid