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MMP13 Antibody

CAT: 0223-57-211Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-211Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
NCBI Gene ID
4322
Swiss Prot
P45452
Accession Number
P45452
Host
Rabbit
Reactivity
Human
Immunogen
This MMP13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 253-282 amino acids from the Central region of human MMP13.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Rb
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
54 kDa
Fragment
Rabbit Ig
Symbol
MMP13
NCBI Official Name
Collagenase 3
NCBI Organism
Homo sapiens
Background Reference 01
Miranda, K.J., et al. J. Biol. Chem. 285 (41) :31517-31524 (2010)
Background Reference 02
Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :
Background Reference 03
Nikopensius, T., et al. Birth Defects Res. PartClin. Mol. Teratol. 88 (9) :748-756 (2010)
Background Reference 04
Yamada, T., et al. Anticancer Res. 30 (7) :2693-2699 (2010)
Other Product Names
Collagenase 3, 3424-, Matrix metalloproteinase-13, MMP-13, MMP13
Tested Applications
WB, IHC-P, IF
Protein ID
1168998
Physical Properties
Liquid

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