MMP13 Antibody

• Background:

  Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.

• NCBI Gene ID:

  4322

• Swiss Prot:

  P45452

• Accession Number:

  P45452

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This MMP13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 253-282 amino acids from the Central region of human MMP13.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Rb

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  54 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  MMP13

• NCBI Official Name:

  Collagenase 3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Miranda, K.J., et al. J. Biol. Chem. 285 (41) :31517-31524 (2010)

• Background Reference 02:

  Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :

• Background Reference 03:

  Nikopensius, T., et al. Birth Defects Res. PartClin. Mol. Teratol. 88 (9) :748-756 (2010)

• Background Reference 04:

  Yamada, T., et al. Anticancer Res. 30 (7) :2693-2699 (2010)

• Other Product Names:

  Collagenase 3, 3424-, Matrix metalloproteinase-13, MMP-13, MMP13

• Tested Applications:

  WB, IHC-P, IF

• Protein ID:

  1168998

• Physical Properties:

  Liquid