MMP14 Antibody

CAT: 0223-62-171Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-62-171Size:400 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP14 seems to specifically activate progelatinase A, and may thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. Expression is significant in stromal cells of colon, breast, and head and neck.
NCBI Gene ID
4323
Swiss Prot
P50281
Accession Number
P50281
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This MMP14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 145-174 amino acids from the N-terminal region of human MMP14.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle, Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Rat, Pig, Bovine
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
66 kDa
Fragment
Rabbit Ig
Symbol
MMP14
NCBI Official Name
Matrix metalloproteinase-14
NCBI Organism
Homo sapiens
Background Reference 01
Will, H., et al., Eur. J. Biochem. 231 (3) :602-608 (1995) .
Background Reference 02
Takino, T., et al., Gene 155 (2) :293-298 (1995) .
Background Reference 03
Okada, A., et al., Proc. Natl. Acad. Sci. U.S.A. 92 (7) :2730-2734 (1995) .
Background Reference 04
Sato, H., et al., Nature 370 (6484) :61-65 (1994) .
Other Product Names
Matrix metalloproteinase-14, MMP-14, MMP-X1, Membrane-type matrix metalloproteinase 1, MT-MMP 1, MTMMP1, Membrane-type-1 matrix metalloproteinase, MT1-MMP, MT1MMP, MMP14
Tested Applications
WB, IHC-P, Flow
Protein ID
317373419
Physical Properties
Liquid

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