MMP14 Antibody

• Background:

  Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. MMP14 seems to specifically activate progelatinase A, and may thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. Expression is significant in stromal cells of colon, breast, and head and neck.

• NCBI Gene ID:

  4323

• Swiss Prot:

  P50281

• Accession Number:

  P50281

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This MMP14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 145-174 amino acids from the N-terminal region of human MMP14.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Cell Cycle, Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Rat, Pig, Bovine

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  66 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  MMP14

• NCBI Official Name:

  Matrix metalloproteinase-14

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Will, H., et al., Eur. J. Biochem. 231 (3) :602-608 (1995) .

• Background Reference 02:

  Takino, T., et al., Gene 155 (2) :293-298 (1995) .

• Background Reference 03:

  Okada, A., et al., Proc. Natl. Acad. Sci. U.S.A. 92 (7) :2730-2734 (1995) .

• Background Reference 04:

  Sato, H., et al., Nature 370 (6484) :61-65 (1994) .

• Other Product Names:

  Matrix metalloproteinase-14, MMP-14, MMP-X1, Membrane-type matrix metalloproteinase 1, MT-MMP 1, MTMMP1, Membrane-type-1 matrix metalloproteinase, MT1-MMP, MT1MMP, MMP14

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  317373419

• Physical Properties:

  Liquid