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SILV Antibody

CAT: 0223-57-246Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-246Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
SILV plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures. Release of the soluble form, ME20-S, could protect tumor cells from antibody mediated immunity.
NCBI Gene ID
6490
Swiss Prot
P40967
Accession Number
P40967
Host
Rabbit
Reactivity
Human
Immunogen
This SILV antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 412-440 amino acids from the Central region of human SILV.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
70 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
PMEL
NCBI Official Name
Melanocyte protein PMEL
NCBI Organism
Homo sapiens
Background Reference 01
Leonhardt, R.M., et al. J. Biol. Chem. 285 (21) :16166-16183 (2010)
Background Reference 02
Hoashi, T., et al. FASEB J. 24 (3) :916-930 (2010)
Background Reference 03
Watt, B., et al. J. Biol. Chem. 284 (51) :35543-35555 (2009)
Background Reference 04
McGlinchey, R.P., et al. Proc. Natl. Acad. Sci. U.S.A. 106 (33) :13731-13736 (2009)
Other Product Names
Melanocyte protein PMEL, ME20-M, ME20M, Melanocyte protein Pmel 17, Melanocytes lineage-specific antigen GP100, Melanoma-associated ME20 antigen, P1, P100, Premelanosome protein, Silver locus protein homolog, M-alpha, 95 kDa melanocyte-specific secreted glycoprotein, P26, Secreted melanoma-associated ME20 antigen, ME20-S, ME20S, M-beta, PMEL, D12S53E, PMEL17, SILV
Tested Applications
WB
Protein ID
2507099
Physical Properties
Liquid

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