SILV Antibody

• Background:

  SILV plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures. Release of the soluble form, ME20-S, could protect tumor cells from antibody mediated immunity.

• NCBI Gene ID:

  6490

• Swiss Prot:

  P40967

• Accession Number:

  P40967

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This SILV antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 412-440 amino acids from the Central region of human SILV.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  70 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  PMEL

• NCBI Official Name:

  Melanocyte protein PMEL

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Leonhardt, R.M., et al. J. Biol. Chem. 285 (21) :16166-16183 (2010)

• Background Reference 02:

  Hoashi, T., et al. FASEB J. 24 (3) :916-930 (2010)

• Background Reference 03:

  Watt, B., et al. J. Biol. Chem. 284 (51) :35543-35555 (2009)

• Background Reference 04:

  McGlinchey, R.P., et al. Proc. Natl. Acad. Sci. U.S.A. 106 (33) :13731-13736 (2009)

• Other Product Names:

  Melanocyte protein PMEL, ME20-M, ME20M, Melanocyte protein Pmel 17, Melanocytes lineage-specific antigen GP100, Melanoma-associated ME20 antigen, P1, P100, Premelanosome protein, Silver locus protein homolog, M-alpha, 95 kDa melanocyte-specific secreted glycoprotein, P26, Secreted melanoma-associated ME20 antigen, ME20-S, ME20S, M-beta, PMEL, D12S53E, PMEL17, SILV

• Tested Applications:

  WB

• Protein ID:

  2507099

• Physical Properties:

  Liquid