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GRM6 Antibody

CAT: 0223-57-233Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-233Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
NCBI Gene ID
2916
Swiss Prot
O15303
Accession Number
O15303
Host
Rabbit
Reactivity
Human
Immunogen
This GRM6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 369-398 amino acids from the Central region of human GRM6.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Signal Transduction, Growth Factors
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
95 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
GRM6
NCBI Official Name
Metabotropic glutamate receptor 6
NCBI Organism
Homo sapiens
Background Reference 01
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Background Reference 02
Fonseca, F., et al. Mol Diagn Ther 14 (3) :171-178 (2010)
Background Reference 03
Beqollari, D., et al. Mol. Pharmacol. 76 (5) :992-997 (2009)
Background Reference 04
Need, A.C., et al. Eur. J. Hum. Genet. 17 (7) :946-957 (2009)
Other Product Names
Metabotropic glutamate receptor 6, mGluR6, GRM6, GPRC1F, MGLUR6
Tested Applications
WB
Physical Properties
Liquid

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