GRM4 Antibody

CAT: 0223-22-834Size: 100 µLDry Ice: NoHazardous: No
CAT#:0223-22-834Size:100 µL
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Background
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Several transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
2914
Swiss Prot
Q14833
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 33-290 of human GRM4 (NP_000832.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Cell Cycle, Neuroscience, Signal Transduction
Purification
Affinity purification
Positive Control
Mouse spinal cord
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 115kDa
Fragment
IgG
Symbol
GRM4
Positive Control 2
Rat brain
NCBI Official Name
Glutamate metabotropic receptor 4
NCBI Organism
Homo sapiens
Other Product Names
GPRC1D, MGLUR4, mGlu4, metabotropic glutamate receptor 4, glutamate receptor, metabotropic 4
Tested Applications
WB, IHC, IF
Physical Properties
Liquid

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