GRM2 Antibody

CAT: 0223-13-724Size: 100 µLDry Ice: NoHazardous: No
CAT#:0223-13-724Size:100 µL
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Background
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Two transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
2912
Swiss Prot
Q14416
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 410-540 of human GRM2 (NP_000830.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Signal Transduction
Purification
Affinity purification
Positive Control
U-251MG
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 110kDa
Fragment
IgG
Applications Notes
WB: 1:1000 - 1:2000
Symbol
GRM2
Positive Control 2
HeLa
Positive Control 3
HepG2
Positive Control 4
Mouse liver
Positive Control 5
Mouse kidney
NCBI Official Name
Glutamate receptor, metabotropic 2
NCBI Organism
Homo sapiens
Other Product Names
GRM2, MGLUR2, mGlu2, GPRC1B, glutamate receptor, metabotropic 2, glutamate receptor homolog, glutamate metabotropic receptor 2, GLUR2
Tested Applications
WB
Physical Properties
Liquid

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