GRM2 Antibody

• Background:

  L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Two transcript variants encoding different isoforms have been found for this gene.

• NCBI Gene ID:

  2912

• Swiss Prot:

  Q14416

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 410-540 of human GRM2 (NP_000830.2) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience, Signal Transduction

• Purification:

  Affinity purification

• Positive Control:

  U-251MG

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 110kDa

• Fragment:

  IgG

• Applications Notes:

  WB: 1:1000 - 1:2000

• Symbol:

  GRM2

• Positive Control 2:

  HeLa

• Positive Control 3:

  HepG2

• Positive Control 4:

  Mouse liver

• Positive Control 5:

  Mouse kidney

• NCBI Official Name:

  Glutamate receptor, metabotropic 2

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  GRM2, MGLUR2, mGlu2, GPRC1B, glutamate receptor, metabotropic 2, glutamate receptor homolog, glutamate metabotropic receptor 2, GLUR2

• Tested Applications:

  WB

• Physical Properties:

  Liquid