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GRM1 Antibody

CAT: 0223-57-210Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-210Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. The canonical alpha isoform of the metabotropic glutamate receptor 1 gene is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. Alternative splicing results in multiple transcript variants encoding distinct isoforms; some of which may have distinct functions. [provided by RefSeq].
NCBI Gene ID
2911
Swiss Prot
Q13255
Accession Number
Q13255
Host
Rabbit
Reactivity
Human
Immunogen
This GRM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1095-1123 amino acids from the C-terminal region of human GRM1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Growth Factors
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
132 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
GRM1
NCBI Official Name
Metabotropic glutamate receptor 1
NCBI Organism
Homo sapiens
Background Reference 01
Jiang, Y., et al. J. Biol. Chem. 285 (43) :33463-33474 (2010)
Background Reference 02
Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)
Background Reference 03
Gong, P., et al. J. Mol. Neurosci. 42 (1) :120-126 (2010)
Background Reference 04
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Other Product Names
Metabotropic glutamate receptor 1, mGluR1, GRM1, GPRC1A, MGLUR1
Tested Applications
WB
Protein ID
311033443
Physical Properties
Liquid

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