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HDAC4 Antibody

CAT: 0223-57-218Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-218Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.
NCBI Gene ID
9759
Swiss Prot
P56524
Accession Number
P56524
Host
Rabbit
Reactivity
Human
Immunogen
This HDAC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1049-1077 amino acids from the C-terminal region of human HDAC4.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
119 kDa
Fragment
Rabbit Ig
Symbol
HDAC4
NCBI Official Name
Histone deacetylase 4
NCBI Organism
Homo sapiens
Background Reference 01
Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)
Background Reference 02
Williams, S.R., et al. Am. J. Hum. Genet. 87 (2) :219-228 (2010)
Background Reference 03
Kim, T., et al. Psychiatry Res 178 (2) :266-269 (2010)
Background Reference 04
Pan, L., et al. Cell. Mol. Immunol. 7 (3) :221-226 (2010)
Other Product Names
Histone deacetylase 4, HD4, HDAC4, KIAA0288
Tested Applications
WB, IHC-P, IF
Protein ID
259016348
Physical Properties
Liquid

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