DOK7 Antibody

• Background:

  The protein encoded by this gene is essential for neuromuscular synaptogenesis. The protein functions in aneural activation of muscle-specific receptor kinase, which is required for postsynaptic differentiation, and in the subsequent clustering of the acetylcholine receptor in myotubes. This protein can also induce autophosphorylation of muscle-specific receptor kinase. Mutations in this gene are a cause of familial limb-girdle myasthenia autosomal recessive, which is also known as congenital myasthenic syndrome type 1B. Alternative splicing results in multiple transcript variants.

• NCBI Gene ID:

  285489

• Swiss Prot:

  Q18PE1

• Accession Number:

  Q18PE1

• Host:

  Rabbit

• Reactivity:

  Mouse

• Immunogen:

  This DOK7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-55 amino acids from the N-terminal region of human DOK7.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  53 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  DOK7

• NCBI Official Name:

  Protein Dok-7

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Bergamin, E., et al. Mol. Cell 39 (1) :100-109 (2010)

• Background Reference 02:

  Srour, M., et al. Neuromuscul. Disord. 20 (7) :453-457 (2010)

• Background Reference 03:

  Maselli, R.A., et al. Hum. Mol. Genet. 19 (12) :2370-2379 (2010)

• Background Reference 04:

  Ben Ammar, A., et al. J. Neurol. 257 (5) :754-766 (2010)

• Other Product Names:

  Protein Dok-7, Downstream of tyrosine kinase 7, DOK7, C4orf25

• Tested Applications:

  WB

• Protein ID:

  115311705

• Physical Properties:

  Liquid