DOK3 Antibody

• Background:

  DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate Abl function (By similarity) .

• NCBI Gene ID:

  79930

• Swiss Prot:

  Q7L591

• Accession Number:

  Q7L591

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This DOK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 293-321 amino acids from the C-terminal region of human DOK3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  53 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  DOK3

• NCBI Official Name:

  Docking protein 3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Berger, A.H., et al. Nat. Genet. 42 (3) :216-223 (2010)

• Background Reference 02:

  Senis, Y.A., et al. J. Thromb. Haemost. 7 (10) :1718-1726 (2009)

• Background Reference 03:

  Honma, M., et al. Genes Cells 11 (2) :143-151 (2006)

• Background Reference 04:

  Robson, J.D., et al. Mol. Cell. Biol. 24 (6) :2332-2343 (2004)

• Other Product Names:

  Docking protein 3, Downstream of tyrosine kinase 3, DOK3

• Tested Applications:

  WB, IHC-P

• Protein ID:

  84029599

• Physical Properties:

  Liquid