DOK1 Antibody

CAT: 0223-1107-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-1107-01Size:0.02 mg
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Background
DOK1 Antibody: Signals from most growth factors and cytokines are transduced by receptor tyrosine kinases or non-receptor tyrosine kinases. Activated tyrosine kinases phosphorylate their substrates, which mediate the cellular response to extracellular stimuli. A long-sought major substrate termed p62dok (downstream of tyrosine kinase) for many tyrosine kinases including c-kit, v-abl, v-Fps, v-Src, v-Fms, and activated EGF, PDGF, IGF, VEGF and insulin receptors was identified recently from human and mouse by several laboratories. Upon phosphorylation, p62dok forms a complex with the ras GTPase-activating protein (RasGAP) . p62dok represents a new family with very recently identified p56dok.
NCBI Gene ID
1796
Swiss Prot
Q99704
Accession Number
Q99704.1
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction, Cancer
Purification
DOK1 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1205 - Jurkat Cell Lysate
Concentration
1 mg/ml
Buffer
DOK1 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
DOK1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
62 kDa
Fragment
IgG
Symbol
DOK1
Positive Control 2
Cat. No. 1208 - THP-1 Cell Lysate
Positive Control 3
Cat. No. 1204 - K562 Cell Lysate
Positive Control 4
Cat. No. 17-004 - K-562 Cell Slide
NCBI Official Name
Docking protein 1
NCBI Organism
Homo sapiens
Background Reference 01
Carpino N, Wisniewski D, Strife A, Marshak D, Kobayashi R, Stillman B, Clarkson B p62 (dok) : a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells. Cell 1997;88:197-204.
Background Reference 02
Yamanashi Y, Baltimore D Identification of the Abl- and rasGAP-associated 62 KDa protein as a docking protein, Dok. Cell 1997;88:205-211.
Background Reference 03
Holland SJ, Gale NW, Gish GD, Roth RA, Songyang Z, Cantley LC, Henkemeyer M, Yancopoulos GD, Pawson T. Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells. EMBO J 1997;16:3877-3888.
Background Reference 04
Di Cristofano A, Carpino N, Dunant N, Friedland G, Kobayashi R, Strife A, Wisniewski D, Clarkson B, Pandolfi PP, Resh MD. Molecular cloning and characterization of p56 (dok-2) defines a new family of RasGAP-binding proteins. J Biol Chem 1998;273:4827-4830.
Other Product Names
DOK1 Antibody: Docking protein 1, Downstream of tyrosine kinase 1, P62 (dok), pp62
Tested Applications
ELISA, WB, ICC, IF
Protein ID
17366642
Physical Properties
Liquid

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