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OGDH Antibody

CAT: 0223-57-045Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-045Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO (2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
NCBI Gene ID
4967
Swiss Prot
Q02218
Accession Number
Q02218
Host
Rabbit
Reactivity
Human
Immunogen
This OGDH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 381-410 amino acids from the C-terminal region of human OGDH.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
116 kDa
Fragment
Rabbit Ig
Symbol
OGDH
NCBI Official Name
2-oxoglutarate dehydrogenase, mitochondrial
NCBI Organism
Homo sapiens
Background Reference 01
Van Bever, Y., et al. Am. J. Med. Genet.143 (7) :763-767 (2007)
Background Reference 02
Shi, Q., et al. J. Biol. Chem. 280 (12) :10888-10896 (2005)
Background Reference 03
Habelhah, H., et al. J. Biol. Chem. 279 (51) :53782-53788 (2004)
Background Reference 04
McCartney, R.G., et al. J. Biol. Chem. 273 (37) :24158-24164 (1998)
Other Product Names
2-oxoglutarate dehydrogenase, mitochondrial, 2-oxoglutarate dehydrogenase complex component E1, OGDC-E1, Alpha-ketoglutarate dehydrogenase, OGDH
Tested Applications
WB, IHC-P
Protein ID
160332299
Physical Properties
Liquid

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