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BLNK Antibody

CAT: 0223-57-040Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-57-040Size:400 µL
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Background
This gene encodes a cytoplasmic linker or adaptor protein that plays a critical role in B cell development. This protein bridges B cell receptor-associated kinase activation with downstream signaling pathways, thereby affecting various biological functions. The phosphorylation of five tyrosine residues is necessary for this protein to nucleate distinct signaling effectors following B cell receptor activation. Mutations in this gene cause hypoglobulinemia and absent B cells, a disease in which the pro- to pre-B-cell transition is developmentally blocked. Deficiency in this protein has also been shown in some cases of pre-B acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
29760
Swiss Prot
Q8WV28
Accession Number
Q8WV28
Host
Rabbit
Reactivity
Human
Immunogen
This BLNK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 57-82 amino acids from the N-terminal region of human BLNK.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology, Signal Transduction
Purification
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
50 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
BLNK
NCBI Official Name
B-cell linker protein
NCBI Organism
Homo sapiens
Background Reference 01
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Background Reference 02
Davila, S., et al. Genes Immun. 11 (3) :232-238 (2010)
Background Reference 03
Oellerich, T., et al. Mol. Cell Proteomics 8 (7) :1738-1750 (2009)
Background Reference 04
Imamura, Y., et al. J. Biol. Chem. 284 (15) :9804-9813 (2009)
Other Product Names
B-cell linker protein, B-cell adapter containing a SH2 domain protein, B-cell adapter containing a Src homology 2 domain protein, Cytoplasmic adapter protein, Src homology 2 domain-containing leukocyte protein of 65 kDa, SLP-65, BLNK, BASH, SLP65
Tested Applications
WB
Protein ID
82592659
Physical Properties
Liquid

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