PRCP Antibody

• Background:

  The protein encoded by this gene is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq].

• NCBI Gene ID:

  5547

• Swiss Prot:

  P42785

• Accession Number:

  P42785

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This PRCP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 114-143 amino acids from the N-terminal region of human PRCP.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cell Cycle

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  56 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  PRCP

• NCBI Official Name:

  Lysosomal Pro-X carboxypeptidase

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Bailey, S.D., et al. Diabetes Care 33 (10) :2250-2253 (2010)

• Background Reference 02:

  Zhao, X., et al. Proteomics 10 (15) :2882-2886 (2010)

• Background Reference 03:

  Abeywickrema, P.D., et al. Acta Crystallogr. Sect.Struct. Biol. Cryst. Commun. 66 (PT 6), 702-705 (2010) :

• Background Reference 04:

  Soisson, S.M., et al. BMC Struct. Biol. 10, 16 (2010) :

• Other Product Names:

  Lysosomal Pro-X carboxypeptidase, Angiotensinase C, Lysosomal carboxypeptidase C, Proline carboxypeptidase, Prolylcarboxypeptidase, PRCP, PRCP, PCP

• Tested Applications:

  WB, IHC-P

• Protein ID:

  1172047

• Physical Properties:

  Liquid