ABCC12 Antibody

• Background:

  This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two ATP-binding domains and 12 transmembrane regions. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White. This gene is a member of the MRP subfamily which is involved in multi-drug resistance. This gene and another subfamily member are arranged head-to-tail on chromosome 16q12.1. Increased expression of this gene is associated with breast cancer.

• NCBI Gene ID:

  94160

• Swiss Prot:

  Q96J65

• Accession Number:

  Q96J65

• Host:

  Rabbit

• Reactivity:

  Mouse

• Immunogen:

  This ABCC12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 723-752 amino acids from the Central region of human ABCC12.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  152 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  ABCC12

• NCBI Official Name:

  Multidrug resistance-associated protein 9

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :

• Background Reference 02:

  Haimeur, A., et al. Curr. Drug Metab. 5 (1) :21-53 (2004)

• Background Reference 03:

  Bera, T.K., et al. Proc. Natl. Acad. Sci. U.S.A. 99 (10) :6997-7002 (2002)

• Background Reference 04:

  Yabuuchi, H., et al. Biochem. Biophys. Res. Commun. 288 (4) :933-939 (2001)

• Other Product Names:

  Multidrug resistance-associated protein 9, ATP-binding cassette sub-family C member 12, ABCC12, MRP9

• Tested Applications:

  WB, IHC-P

• Protein ID:

  161788999

• Physical Properties:

  Liquid