ABCC2 Antibody

CAT: 0223-23-561Size: 100 µLDry Ice: NoHazardous: No
CAT#:0223-23-561Size:100 µL
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Background
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White) . This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.
NCBI Gene ID
1244
Swiss Prot
Q92887
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 180-315 of human ABCC2 (NP_000383.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
Affinity purification
Positive Control
HeLa
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 300kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:2000
Symbol
ABCC2
Positive Control 2
HeLa+PNGaseF
NCBI Official Name
ATP binding cassette subfamily C member 2
NCBI Organism
Homo sapiens
Other Product Names
ABC3CMOAT, DJS, MRP2, cMRP, canalicular multispecific organic anion transporter 1, ATP-binding cassette, sub-family C (CFTR/MRP), member 2, canalicular multidrug resistance protein, multidrug resistance-associated protein 2
Tested Applications
WB
Physical Properties
Liquid

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