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CD320 Antibody

CAT: 0223-56-874Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-56-874Size:400 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The CD320 antigen gene encodes the transcobalamin receptor (TCBLR) . Cellular uptake of cobalamin (vitamin B12) is mediated by receptors expressed on the cell surface. Transcobalamin II (TCN2; MIM 613441), a plasma protein secreted by endothelial cells, binds the cobalamin absorbed in the distal ileum and carries 10 to 30% of total circulating cobalamin. CD320 encodes a transcobalamin receptor that binds TCN2-cobalamin at the plasma membrane and internalizes the complex by endocytosis (Quadros et al., 2009 [PubMed 18779389]) .
NCBI Gene ID
51293
Swiss Prot
Q9NPF0
Accession Number
Q9NPF0
Host
Rabbit
Reactivity
Human
Immunogen
This CD320 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 153-182 amino acids from the C-terminal region of human CD320.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Cell Cycle, Immunology
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
29 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
CD320
NCBI Official Name
CD320 antigen
NCBI Organism
Homo sapiens
Background Reference 01
Jiang, W., et al. Gene 466 (1-2), 49-55 (2010) :
Background Reference 02
Pangilinan, F., et al. J. Med. Genet. 47 (10) :677-685 (2010)
Background Reference 03
Quadros, E.V., et al. Hum. Mutat. 31 (8) :924-929 (2010)
Background Reference 04
Quadros, E.V., et al. Blood 113 (1) :186-192 (2009)
Other Product Names
CD320 antigen, 8D6 antigen, FDC-signaling molecule 8D6, FDC-SM-8D6, Transcobalamin receptor, TCblR, CD320, CD320, 8D6A
Tested Applications
WB
Protein ID
74734303
Physical Properties
Liquid

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