SEC63 Antibody

• Background:

  The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER.

• NCBI Gene ID:

  11231

• Swiss Prot:

  Q9UGP8

• Accession Number:

  Q9UGP8

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This SEC63 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 139-168 amino acids from the N-terminal region of human SEC63.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  88 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  SEC63

• NCBI Official Name:

  Translocation protein SEC63 homolog

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Waanders, E., et al. Clin. Genet. 78 (1) :47-56 (2010)

• Background Reference 02:

  Van Keimpema, L., et al. Liver Int. (2010) In press :

• Background Reference 03:

  Waanders, E., et al. Histochem. Cell Biol. 129 (3) :301-310 (2008)

• Background Reference 04:

  You, K.T., et al. PLoS Biol. (5), E109 (2007) :

• Other Product Names:

  Translocation protein SEC63 homolog, SEC63, SEC63L

• Tested Applications:

  WB, IHC-P

• Protein ID:

  18203500

• Physical Properties:

  Liquid