SEC63 Antibody

CAT: 0223-56-867Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-56-867Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER.
NCBI Gene ID
11231
Swiss Prot
Q9UGP8
Accession Number
Q9UGP8
Host
Rabbit
Reactivity
Human
Immunogen
This SEC63 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 139-168 amino acids from the N-terminal region of human SEC63.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
88 kDa
Fragment
Rabbit Ig
Symbol
SEC63
NCBI Official Name
Translocation protein SEC63 homolog
NCBI Organism
Homo sapiens
Background Reference 01
Waanders, E., et al. Clin. Genet. 78 (1) :47-56 (2010)
Background Reference 02
Van Keimpema, L., et al. Liver Int. (2010) In press :
Background Reference 03
Waanders, E., et al. Histochem. Cell Biol. 129 (3) :301-310 (2008)
Background Reference 04
You, K.T., et al. PLoS Biol. (5), E109 (2007) :
Other Product Names
Translocation protein SEC63 homolog, SEC63, SEC63L
Tested Applications
WB, IHC-P
Protein ID
18203500
Physical Properties
Liquid

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