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SEC62 Antibody

CAT: 0223-6471-01Size: 0.02 mgDry Ice: NoHazardous: No
CAT#:0223-6471-01Size:0.02 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
SEC62 Antibody: SEC62 is an integral membrane protein located in the rough endoplasmic reticulum (ER) and is part of the SEC61-SEC62-SEC63 complex that is the central component of the protein translocation apparatus of the ER membrane. It is speculated that SEC61-SEC62-SEC63 may perform post-translational protein translocation into the ER and might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. Silencing of this gene with RNAi dramatically reduced the migration and invasive potential of numerous tumor cell lines, suggesting that it may be an attractive target for therapy of various tumors.
NCBI Gene ID
7095
Swiss Prot
Q99442
Accession Number
NP_003253
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Homeostasis
Purification
SEC62 Antibody is affinity chromatography purified via peptide column.
Positive Control
Cat. No. 1463 - Rat Brain Tissue Lysate
Concentration
1 mg/mL
Homology
Predicted species reactivity based on immunogen sequence: Chicken: (100%)
Buffer
SEC62 Antibody is supplied in PBS containing 0.02% sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
SEC62 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Fragment
IgG
Specificity
SEC62 antibody is predicted to not cross-react with other SEC proteins. Multiple isoforms of SEC62 are known to exist.
Symbol
SEC62
NCBI Official Name
SEC62 homolog (S. cerevisiae)
NCBI Organism
Homo sapiens
Background Reference 01
Deshaies RJ and Scheckman R. SEC62 encodes a putative membrane protein required for protein translocation in the yeast endoplasmic reticulum. J. Cell Biol. 1989; 109:2653-64.
Background Reference 02
Meyer HA, Grau H, Kraft R, et al. Mammalian Sec61 is associated with Sec62 and Sec63. J. Biol. Chem. 2000; 275:14550-7
Background Reference 03
Greiner M, Kreutzer B, Jung V, et al. Silencing of the SEC62 gene inhibits migratory and invasive potential of various tumor cells. Int. J. Cancer 2011; 128:2284-95.
Other Product Names
SEC62 Antibody: HTP1, TP-1, Dtrp1, TLOC1, Translocation protein SEC62, Translocation protein 1
Tested Applications
ELISA, WB, IHC-P, IF
Protein ID
4507525
Physical Properties
Liquid

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