COPZ1 Antibody

CAT: 0223-56-866Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-56-866Size:400 µL
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity) . The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.
NCBI Gene ID
22818
Swiss Prot
P61923
Accession Number
P61923
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
This COPZ1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 24-53 amino acids from the N-terminal region of human COPZ1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Bovine
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
20 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
COPZ1
NCBI Official Name
Coatomer subunit zeta-1
NCBI Organism
Homo sapiens
Background Reference 01
Matsuoka, S., et al. Science 316 (5828) :1160-1166 (2007)
Background Reference 02
Lamesch, P., et al. Genomics 89 (3) :307-315 (2007)
Background Reference 03
Lippincott-Schwartz, J., et al. Trends Cell Biol. 16 (10), E1-E4 (2006) :
Background Reference 04
Wegmann, D., et al. Mol. Cell. Biol. 24 (3) :1070-1080 (2004)
Other Product Names
Coatomer subunit zeta-1, Zeta-1-coat protein, Zeta-1 COP, COPZ1, COPZ
Tested Applications
WB
Protein ID
48428830
Physical Properties
Liquid

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