RASAL1 Antibody

• Background:

  The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. These proteins stimulate the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This particular family member contains domains which are characteristic of the GAP1 subfamily of RasGAP proteins but, in contrast to the other GAP1 family members, this protein is strongly and selectively expressed in endocrine tissues. Alternatively spliced transcript variants that encode different isoforms have been described

• NCBI Gene ID:

  8437

• Swiss Prot:

  O95294

• Accession Number:

  O95294

• Host:

  Rabbit

• Reactivity:

  Mouse

• Immunogen:

  This RASAL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 309-337 amino acids from the Central region of human RASAL1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  90 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  RASAL1

• NCBI Official Name:

  RasGAP-activating-like protein 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Ohta, M., et al. Gastroenterology 136 (1) :206-216 (2009)

• Background Reference 02:

  Jin, H., et al. Proc. Natl. Acad. Sci. U.S.A. 104 (30) :12353-12358 (2007)

• Background Reference 03:

  Liu, Q., et al. J. Cell Biol. 170 (2) :183-190 (2005)

• Background Reference 04:

  Schmitt, J.M., et al. J. Biol. Chem. 277 (45) :43024-43032 (2002)

• Other Product Names:

  RasGAP-activating-like protein 1, RASAL1, RASAL

• Tested Applications:

  WB

• Physical Properties:

  Liquid