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RASAL1 Antibody

CAT: 0223-56-440Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-56-440Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. These proteins stimulate the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This particular family member contains domains which are characteristic of the GAP1 subfamily of RasGAP proteins but, in contrast to the other GAP1 family members, this protein is strongly and selectively expressed in endocrine tissues. Alternatively spliced transcript variants that encode different isoforms have been described
NCBI Gene ID
8437
Swiss Prot
O95294
Accession Number
O95294
Host
Rabbit
Reactivity
Mouse
Immunogen
This RASAL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 309-337 amino acids from the Central region of human RASAL1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
90 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
RASAL1
NCBI Official Name
RasGAP-activating-like protein 1
NCBI Organism
Homo sapiens
Background Reference 01
Ohta, M., et al. Gastroenterology 136 (1) :206-216 (2009)
Background Reference 02
Jin, H., et al. Proc. Natl. Acad. Sci. U.S.A. 104 (30) :12353-12358 (2007)
Background Reference 03
Liu, Q., et al. J. Cell Biol. 170 (2) :183-190 (2005)
Background Reference 04
Schmitt, J.M., et al. J. Biol. Chem. 277 (45) :43024-43032 (2002)
Other Product Names
RasGAP-activating-like protein 1, RASAL1, RASAL
Tested Applications
WB
Physical Properties
Liquid

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