RASAL1 Antibody

• Background:

  The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. These proteins stimulate the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This particular family member contains domains which are characteristic of the GAP1 subfamily of RasGAP proteins but, in contrast to the other GAP1 family members, this protein is strongly and selectively expressed in endocrine tissues. Alternatively spliced transcript variants that encode different isoforms have been described

• NCBI Gene ID:

  8437

• Swiss Prot:

  O95294

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 120-340 of human RASAL1 (NP_004649.2) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Signal Transduction

• Purification:

  Affinity purification

• Positive Control:

  A549

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 110kDa

• Fragment:

  IgG

• Applications Notes:

  WB: 1:500 - 1:2000

• Symbol:

  RASAL1

• Positive Control 2:

  MCF7

• Positive Control 3:

  Mouse brain

• Positive Control 4:

  Rat brain

• NCBI Official Name:

  RAS protein activator like 1 (GAP1 like)

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  RASAL1, RASAL, RAS protein activator like 1 (GAP1 like), GAP1 like protein, RAS-GTPase-activating protein-like

• Tested Applications:

  WB

• Physical Properties:

  Liquid