NPHP3 Antibody

• Background:

  This gene encodes a protein containing a coiled-coil (CC) domain, a tubulin-tyrosine ligase (TTL) domain, and a tetratrico peptide repeat (TPR) domain. The encoded protein interacts with nephrocystin and may function in renal tubular development and function. Mutations in this gene are associated with nephronophthisis type 3. Multiple splice variants have been described but their full-length nature has not been determined.

• NCBI Gene ID:

  27031

• Swiss Prot:

  Q7Z494

• Accession Number:

  Q7Z494

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This NPHP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 144-173 amino acids from the N-terminal region of human NPHP3.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Zebrafish, Xenopus

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  151 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  NPHP3

• NCBI Official Name:

  Nephrocystin-3

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Simpson, M.A., et al. Am. J. Kidney Dis. 53 (5) :790-795 (2009)

• Background Reference 02:

  Tory, K., et al. Kidney Int. 75 (8) :839-847 (2009)

• Background Reference 03:

  Bergmann, C., et al. Am. J. Hum. Genet. 82 (4) :959-970 (2008)

• Background Reference 04:

  Hoefele, J., et al. J. Am. Soc. Nephrol. 18 (10) :2789-2795 (2007)

• Other Product Names:

  Nephrocystin-3, NPHP3, KIAA2000

• Tested Applications:

  WB, IHC-P

• Protein ID:

  68565783

• Physical Properties:

  Liquid