SGPL1 Antibody

• Background:

  SGPL1 cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis.

• NCBI Gene ID:

  8879

• Swiss Prot:

  O95470

• Accession Number:

  O95470

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This SGPL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 72-101 amino acids from the N-terminal region of human SGPL1.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  64 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  SGPL1

• NCBI Official Name:

  Sphingosine-1-phosphate lyase 1

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Seo, Y.J., et al. J. Virol. 84 (16) :8124-8131 (2010)

• Background Reference 02:

  Vogel, P., et al. PLoS ONE (1), E4112 (2009) :

• Background Reference 03:

  Peest, U., et al. J. Cell. Biochem. 104 (3) :756-772 (2008)

• Background Reference 04:

  Morgan, A.R., et al. Am. J. Med. Genet.Neuropsychiatr. Genet. 144B (6), 762-770 (2007) :

• Other Product Names:

  Sphingosine-1-phosphate lyase 1, S1PL, SP-lyase 1, SPL 1, hSPL, Sphingosine-1-phosphate aldolase, SGPL1, KIAA1252

• Tested Applications:

  WB, IHC-P

• Physical Properties:

  Liquid