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IREB2 Antibody

CAT: 0223-56-572Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-56-572Size:400 µL
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
IREB2 is a RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.
NCBI Gene ID
3658
Swiss Prot
P48200
Accession Number
P48200
Host
Rabbit
Reactivity
Human
Immunogen
This IREB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 201-230 amino acids from the Central region of human IREB2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Pig, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
105 kDa
Fragment
Rabbit Ig
Symbol
IREB2
NCBI Official Name
Iron-responsive element-binding protein 2
NCBI Organism
Homo sapiens
Background Reference 01
Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16 (10) :770-777 (2010)
Background Reference 02
Hansen, H.M., et al. Hum. Mol. Genet. 19 (18) :3652-3661 (2010)
Background Reference 03
Cho, M.H., et al. Nat. Genet. 42 (3) :200-202 (2010)
Background Reference 04
Salahudeen, A.A., et al. Science 326 (5953) :722-726 (2009)
Other Product Names
Iron-responsive element-binding protein 2, IRE-BP 2, Iron regulatory protein 2, IRP2, IREB2
Tested Applications
WB, IHC-P, Flow
Protein ID
308153591
Physical Properties
Liquid

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