IREB2 Antibody

• Background:

  IREB2 is a RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.

• NCBI Gene ID:

  3658

• Swiss Prot:

  P48200

• Accession Number:

  P48200

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This IREB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 201-230 amino acids from the Central region of human IREB2.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse, Pig, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  105 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  IREB2

• NCBI Official Name:

  Iron-responsive element-binding protein 2

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16 (10) :770-777 (2010)

• Background Reference 02:

  Hansen, H.M., et al. Hum. Mol. Genet. 19 (18) :3652-3661 (2010)

• Background Reference 03:

  Cho, M.H., et al. Nat. Genet. 42 (3) :200-202 (2010)

• Background Reference 04:

  Salahudeen, A.A., et al. Science 326 (5953) :722-726 (2009)

• Other Product Names:

  Iron-responsive element-binding protein 2, IRE-BP 2, Iron regulatory protein 2, IRP2, IREB2

• Tested Applications:

  WB, IHC-P, Flow

• Protein ID:

  308153591

• Physical Properties:

  Liquid