PCDHA7 Antibody

• Background:

  This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.

• NCBI Gene ID:

  56141

• Swiss Prot:

  Q9UN72

• Accession Number:

  Q9UN72

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This PCDHA7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 272-300 amino acids from the Central region of human PCDHA7.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Neuroscience, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  101 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  PCDHA7

• NCBI Official Name:

  Protocadherin alpha-7

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Wu, C., et al. Proteomics 7 (11) :1775-1785 (2007)

• Background Reference 02:

  Wu, Q., et al. Genome Res. 11 (3) :389-404 (2001)

• Background Reference 03:

  Nollet, F., et al. J. Mol. Biol. 299 (3) :551-572 (2000)

• Background Reference 04:

  Yagi, T., et al. Genes Dev. 14 (10) :1169-1180 (2000)

• Other Product Names:

  Protocadherin alpha-7, PCDH-alpha-7, PCDHA7, CNRS4

• Tested Applications:

  WB, IHC-P

• Protein ID:

  13878422

• Physical Properties:

  Liquid