PCDHA5 Antibody

CAT: 0223-56-168Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-56-168Size:400 µL
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Background
This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.
NCBI Gene ID
56143
Swiss Prot
Q9Y5H7
Accession Number
Q9Y5H7
Host
Rabbit
Reactivity
Human
Immunogen
This PCDHA5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 287-315 amino acids from the Central region of human PCDHA5.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
102 kDa
Fragment
Rabbit Ig
Symbol
PCDHA5
NCBI Official Name
Protocadherin alpha-5
NCBI Organism
Homo sapiens
Background Reference 01
Wu, C., et al. Proteomics 7 (11) :1775-1785 (2007)
Background Reference 02
Wu, Q., et al. Genome Res. 11 (3) :389-404 (2001)
Background Reference 03
Nollet, F., et al. J. Mol. Biol. 299 (3) :551-572 (2000)
Background Reference 04
Yagi, T., et al. Genes Dev. 14 (10) :1169-1180 (2000)
Other Product Names
Protocadherin alpha-5, PCDH-alpha-5, PCDHA5, CNRS6
Tested Applications
WB, IHC-P
Protein ID
13878428
Physical Properties
Liquid

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