PCDHA3 Antibody

• Background :

  This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.

• NCBI Gene ID :

  56145

• Swiss Prot :

  Q9Y5H8

• Accession Number :

  Q9Y5H8

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This PCDHA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 773-800 amino acids from the C-terminal region of human PCDHA3.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Neuroscience, Signal Transduction

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  102 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  PCDHA3

• NCBI Official Name :

  Protocadherin alpha-3

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Gregorio, S.P., et al. Psychiatry Res 165 (1-2), 1-9 (2009) :

• Background Reference 02 :

  Wu, C., et al. Proteomics 7 (11) :1775-1785 (2007)

• Background Reference 03 :

  Wu, Q., et al. Genome Res. 11 (3) :389-404 (2001)

• Background Reference 04 :

  Nollet, F., et al. J. Mol. Biol. 299 (3) :551-572 (2000)

• Other Product Names :

  Protocadherin alpha-3, PCDH-alpha-3, PCDHA3

• Tested Applications :

  WB, IHC-P

• Protein ID :

  13878429

• Physical Properties :

  Liquid