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BPGM Antibody

CAT: 0223-56-539Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-56-539Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
2,3-diphosphoglycerate (2,3-DPG) is a small molecule found at high concentrations in red blood cells where it binds to and decreases the oxygen affinity of hemoglobin. This gene encodes a multifunctional enzyme that catalyzes 2,3-DPG synthesis via its synthetase activity, and 2,3-DPG degradation via its phosphatase activity. The enzyme also has phosphoglycerate phosphomutase activity. Deficiency of this enzyme increases the affinity of cells for oxygen. Mutations in this gene result in hemolytic anemia. Multiple alternatively spliced variants, encoding the same protein, have been identified.
NCBI Gene ID
669
Swiss Prot
P07738
Accession Number
P07738
Host
Rabbit
Reactivity
Human
Immunogen
This BPGM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 230-259 amino acids from the C-terminal region of human BPGM.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Monkey
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
30 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:2000
Symbol
BPGM
NCBI Official Name
Bisphosphoglycerate mutase
NCBI Organism
Homo sapiens
Background Reference 01
Lamesch, P., et al. Genomics 89 (3) :307-315 (2007)
Background Reference 02
Wang, Y., et al. J. Biol. Chem. 281 (51) :39642-39648 (2006)
Background Reference 03
Wang, Y., et al. J. Biol. Chem. 279 (37) :39132-39138 (2004)
Background Reference 04
Fujita, T., et al. J. Biochem. 124 (6) :1237-1244 (1998)
Other Product Names
Bisphosphoglycerate mutase, BPGM,3-bisphosphoglycerate mutase, erythrocyte,3-bisphosphoglycerate synthase,3-diphosphoglycerate mutase, DPGM, BPG-dependent PGAM, BPGM
Tested Applications
WB
Protein ID
130350
Physical Properties
Liquid

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