BPGM Antibody

• Background:

  2,3-diphosphoglycerate (2,3-DPG) is a small molecule found at high concentrations in red blood cells where it binds to and decreases the oxygen affinity of hemoglobin. This gene encodes a multifunctional enzyme that catalyzes 2,3-DPG synthesis via its synthetase activity, and 2,3-DPG degradation via its phosphatase activity. The enzyme also has phosphoglycerate phosphomutase activity. Deficiency of this enzyme increases the affinity of cells for oxygen. Mutations in this gene result in hemolytic anemia. Multiple alternatively spliced variants, encoding the same protein, have been identified.

• NCBI Gene ID:

  669

• Swiss Prot:

  P07738

• Accession Number:

  P07738

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This BPGM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 230-259 amino acids from the C-terminal region of human BPGM.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Obesity, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Monkey

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  30 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:2000

• Symbol:

  BPGM

• NCBI Official Name:

  Bisphosphoglycerate mutase

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Lamesch, P., et al. Genomics 89 (3) :307-315 (2007)

• Background Reference 02:

  Wang, Y., et al. J. Biol. Chem. 281 (51) :39642-39648 (2006)

• Background Reference 03:

  Wang, Y., et al. J. Biol. Chem. 279 (37) :39132-39138 (2004)

• Background Reference 04:

  Fujita, T., et al. J. Biochem. 124 (6) :1237-1244 (1998)

• Other Product Names:

  Bisphosphoglycerate mutase, BPGM,3-bisphosphoglycerate mutase, erythrocyte,3-bisphosphoglycerate synthase,3-diphosphoglycerate mutase, DPGM, BPG-dependent PGAM, BPGM

• Tested Applications:

  WB

• Protein ID:

  130350

• Physical Properties:

  Liquid