MLXIPL Antibody

• Background:

  This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. The gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23.

• NCBI Gene ID:

  51085

• Swiss Prot:

  Q9NP71

• Accession Number:

  Q9NP71

• Host:

  Rabbit

• Reactivity:

  Human, Mouse

• Immunogen:

  This MLXIPL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 624-653 amino acids from the C-terminal region of human MLXIPL.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Cancer, Obesity

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  93 kDa

• Fragment:

  Rabbit Ig

• Symbol:

  MLXIPL

• NCBI Official Name:

  Carbohydrate-responsive element-binding protein

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Hu, M., et al. Pharmacogenet. Genomics 20 (10) :634-637 (2010)

• Background Reference 02:

  Johansen, C.T., et al. Nat. Genet. 42 (8) :684-687 (2010)

• Background Reference 03:

  Keebler, M.E., et al. Circ Cardiovasc Genet 3 (4) :358-364 (2010)

• Background Reference 04:

  Chidambaram, M., et al. Metab. Clin. Exp. (2010) In press :

• Other Product Names:

  Carbohydrate-responsive element-binding protein, ChREBP, Class D basic helix-loop-helix protein 14, bHLHd14, MLX interactor, MLX-interacting protein-like, WS basic-helix-loop-helix leucine zipper protein, WS-bHLH, Williams-Beuren syndrome chromosomal region 14 protein, MLXIPL, BHLHD14, MIO, WBSCR14

• Tested Applications:

  WB, IHC-P

• Protein ID:

  20140871

• Physical Properties:

  Liquid