MLXIP Antibody

• Background:

  MLXIP Antibody: MLXIP is a member of the Myc superfamily of transcription factors and functions as part of a heterodimer with Max-like protein X (MLX) to activate transcription (1) . MLXIP contributes to the regulation of glucose homeostasis as the MLXIP/MLX heterodimer activates expression of thioredoxin-interacting protein (TXNIP), a potent inhibitor of cellular glucose uptake and aerobic glycolysis. The mammalian target of rapamycin (mTOR) suppresses the activation of the TXNIP pathway by binding to MLXIP, thereby preventing the MLXIP/MLX heterodimer formation (2) . MLXIP interaction with Myc may also be involved in metabolic reprogramming and tumorigenesis (3) .

• NCBI Gene ID:

  22877

• Swiss Prot:

  Q9HAP2

• Accession Number:

  NP_055753

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  MLXIP antibody was raised against a peptide corresponding to 19 amino acids near the amino terminus of human MLXIP.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Homeostasis

• Purification:

  MLXIP Antibody is affinity chromatography purified via peptide column.

• Positive Control:

  Cat. No. 1219 - MCF7 Cell Lysate

• Concentration:

  1 mg/mL

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse: (95%)

• Buffer:

  MLXIP Antibody is supplied in PBS containing 0.02% sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  MLXIP antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Fragment:

  IgG

• Symbol:

  MLXIP

• NCBI Official Name:

  MLX interacting protein

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Billin AN, Eilers AL, Coulter KL, et al. MondoA, a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network. Mol. Cell Biol. 2000; 20:8845-54.

• Background Reference 02:

  Kaadige MR, Yang J, Wilde BR, et al. MondoA-Mlx transcriptional activity is limited by mTOR-MondoA interaction. Mol. Cell Biol. 2015; 35:101-10.

• Background Reference 03:

  Carroll PA, Diolaiti D, McFerrin L, et al. Deregulated Myc requires ModoA/Mlx for metabolic reprogramming and tumorigenesis. Cancer Cell 2015; 27:271-85.

• Other Product Names:

  MLXIP Antibody: FB22, HM89, LAP3, LCR1, NPYR, WHIM, CD184, LESTR, NPY3R, NPYRL, HSY3RR, NPYY3R, D2S201E

• Tested Applications:

  ELISA, WB

• Protein ID:

  111955326

• Physical Properties:

  Liquid