NKAP Antibody

• Background:

  This gene encodes a protein that is involved in the activation of the ubiquitous transcription factor NF-kappaB. This protein is associated with the the histone deacetylase HDAC3 and with the Notch corepressor complex, and it thereby acts as a transcriptional repressor of Notch target genes. It is also required for alphabeta T cell development. A related pseudogene has been identified on chromosome X, while a related and intronless retrocopy, which has an intact CDS and may be functional, is located on chromosome 6.

• NCBI Gene ID:

  79576

• Swiss Prot:

  Q8N5F7

• Accession Number:

  Q8N5F7

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This NKAP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 387-415 amino acids from the C-terminal region of human NKAP.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology, Signal Transduction

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Homology:

  Predicted species reactivity based on immunogen sequence: Mouse, Rat

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  47 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  NKAP

• NCBI Official Name:

  NF-kappa-B-activating protein

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  D'Addabbo, A., et al. Artif Intell Med 46 (2) :131-138 (2009)

• Background Reference 02:

  Pajerowski, A.G., et al. Immunity 30 (5) :696-707 (2009)

• Background Reference 03:

  Lamesch, P., et al. Genomics 89 (3) :307-315 (2007)

• Background Reference 04:

  Chen, D., et al. Biochem. Biophys. Res. Commun. 310 (3) :720-724 (2003)

• Other Product Names:

  NF-kappa-B-activating protein, NKAP

• Tested Applications:

  WB

• Protein ID:

  74728990

• Physical Properties:

  Liquid