GBA3 Antibody

• Background :

  GBA3, or cytosolic beta-glucosidase (EC 3.2.1.21), is a predominantly liver enzyme that efficiently hydrolyzes beta-D-glucoside and beta-D-galactoside, but not any known physiologic beta-glycoside, suggesting that it may be involved in detoxification of plant glycosides (de Graaf et al., 2001 [PubMed 11389701]) . GBA3 also has significant neutral glycosylceramidase activity (EC 3.2.1.62), suggesting that it may be involved in a nonlysosomal catabolic pathway of glucosylceramide metabolism (Hayashi et al., 2007 [PubMed 17595169]) .

• NCBI Gene ID :

  57733

• Swiss Prot :

  Q9H227

• Accession Number :

  Q9H227

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This GBA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-325 amino acids from the C-terminal region of human GBA3.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Obesity, Signal Transduction

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  54 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  GBA3

• NCBI Official Name :

  Cytosolic beta-glucosidase

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Dekker, N., et al. Blood Cells Mol. Dis. (2010) In press :

• Background Reference 02 :

  Noguchi, J., et al. Biochem. Biophys. Res. Commun. 374 (3) :549-552 (2008)

• Background Reference 03 :

  Hayashi, Y., et al. J. Biol. Chem. 282 (42) :30889-30900 (2007)

• Background Reference 04 :

  Tribolo, S., et al. J. Mol. Biol. 370 (5) :964-975 (2007)

• Other Product Names :

  Cytosolic beta-glucosidase, Cytosolic beta-glucosidase-like protein 1, GBA3, CBG, CBGL1

• Tested Applications :

  WB, IHC-P

• Protein ID :

  77416427

• Physical Properties :

  Liquid