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GBA3 Antibody

CAT: 0223-56-324Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-56-324Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
GBA3, or cytosolic beta-glucosidase (EC 3.2.1.21), is a predominantly liver enzyme that efficiently hydrolyzes beta-D-glucoside and beta-D-galactoside, but not any known physiologic beta-glycoside, suggesting that it may be involved in detoxification of plant glycosides (de Graaf et al., 2001 [PubMed 11389701]) . GBA3 also has significant neutral glycosylceramidase activity (EC 3.2.1.62), suggesting that it may be involved in a nonlysosomal catabolic pathway of glucosylceramide metabolism (Hayashi et al., 2007 [PubMed 17595169]) .
NCBI Gene ID
57733
Swiss Prot
Q9H227
Accession Number
Q9H227
Host
Rabbit
Reactivity
Human
Immunogen
This GBA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-325 amino acids from the C-terminal region of human GBA3.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Obesity, Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
54 kDa
Fragment
Rabbit Ig
Symbol
GBA3
NCBI Official Name
Cytosolic beta-glucosidase
NCBI Organism
Homo sapiens
Background Reference 01
Dekker, N., et al. Blood Cells Mol. Dis. (2010) In press :
Background Reference 02
Noguchi, J., et al. Biochem. Biophys. Res. Commun. 374 (3) :549-552 (2008)
Background Reference 03
Hayashi, Y., et al. J. Biol. Chem. 282 (42) :30889-30900 (2007)
Background Reference 04
Tribolo, S., et al. J. Mol. Biol. 370 (5) :964-975 (2007)
Other Product Names
Cytosolic beta-glucosidase, Cytosolic beta-glucosidase-like protein 1, GBA3, CBG, CBGL1
Tested Applications
WB, IHC-P
Protein ID
77416427
Physical Properties
Liquid

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