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GREM1 Antibody

CAT: 0223-56-300Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-56-300Size:400 µL
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Background
This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
26585
Swiss Prot
O60565
Accession Number
O60565
Host
Rabbit
Reactivity
Human
Immunogen
This GREM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 111-139 amino acids from the C-terminal region of human GREM1.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
21 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
GREM1
NCBI Official Name
Gremlin-1
NCBI Organism
Homo sapiens
Background Reference 01
Kupfer, S.S., et al. Gastroenterology 139 (5) :1677-1685 (2010)
Background Reference 02
Dimitrov, B.I., et al. J. Med. Genet. 47 (8) :569-574 (2010)
Background Reference 03
McKnight, A.J., et al. J. Am. Soc. Nephrol. 21 (5) :773-781 (2010)
Background Reference 04
Van Vlodrop, I.J., et al. Am. J. Pathol. 176 (2) :575-584 (2010)
Other Product Names
Gremlin-1, Cell proliferation-inducing gene 2 protein, Cysteine knot superfamily 1, BMP antagonist 1, DAN domain family member 2, Down-regulated in Mos-transformed cells protein, Increased in high glucose protein 2, IHG-2, GREM1, CKTSF1B1, DAND2, DRM
Tested Applications
WB
Physical Properties
Liquid

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