ATF4 Antibody

• Background:

  This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2) . The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromsome at q28 in a region containing a large inverted duplication.

• NCBI Gene ID:

  468

• Swiss Prot:

  P18848

• Accession Number:

  P18848

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  This ATF4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 171-198 amino acids from the Central region of human ATF4.

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Other

• Purification:

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration:

  Batch dependent

• Buffer:

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight:

  39 kDa

• Fragment:

  Rabbit Ig

• Applications Notes:

  For WB starting dilution is: 1:1000

• Symbol:

  ATF4

• NCBI Official Name:

  Cyclic AMP-dependent transcription factor ATF-4

• NCBI Organism:

  Homo sapiens

• Background Reference 01:

  Dey, S., et al. J. Biol. Chem. 285 (43) :33165-33174 (2010)

• Background Reference 02:

  Frank, C.L., et al. J. Biol. Chem. 285 (43) :33324-33337 (2010)

• Background Reference 03:

  Rzymski, T., et al. Oncogene 29 (31) :4424-4435 (2010)

• Background Reference 04:

  Liew, C.W., et al. J. Clin. Invest. 120 (8) :2876-2888 (2010)

• Other Product Names:

  Cyclic AMP-dependent transcription factor ATF-4, cAMP-dependent transcription factor ATF-4, Activating transcription factor 4, Cyclic AMP-responsive element-binding protein 2, CREB-2, cAMP-responsive element-binding protein 2, DNA-binding protein TAXREB67, Tax-responsive enhancer element-binding protein 67, TaxREB67, ATF4, CREB2, TXREB

• Tested Applications:

  WB

• Protein ID:

  116241262

• Physical Properties:

  Liquid