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ATF4 Antibody

CAT: 0223-56-296Size: 400 µLDry Ice: NoHazardous: No
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CAT#:0223-56-296Size:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2) . The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromsome at q28 in a region containing a large inverted duplication.
NCBI Gene ID
468
Swiss Prot
P18848
Accession Number
P18848
Host
Rabbit
Reactivity
Human
Immunogen
This ATF4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 171-198 amino acids from the Central region of human ATF4.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
39 kDa
Fragment
Rabbit Ig
Applications Notes
For WB starting dilution is: 1:1000
Symbol
ATF4
NCBI Official Name
Cyclic AMP-dependent transcription factor ATF-4
NCBI Organism
Homo sapiens
Background Reference 01
Dey, S., et al. J. Biol. Chem. 285 (43) :33165-33174 (2010)
Background Reference 02
Frank, C.L., et al. J. Biol. Chem. 285 (43) :33324-33337 (2010)
Background Reference 03
Rzymski, T., et al. Oncogene 29 (31) :4424-4435 (2010)
Background Reference 04
Liew, C.W., et al. J. Clin. Invest. 120 (8) :2876-2888 (2010)
Other Product Names
Cyclic AMP-dependent transcription factor ATF-4, cAMP-dependent transcription factor ATF-4, Activating transcription factor 4, Cyclic AMP-responsive element-binding protein 2, CREB-2, cAMP-responsive element-binding protein 2, DNA-binding protein TAXREB67, Tax-responsive enhancer element-binding protein 67, TaxREB67, ATF4, CREB2, TXREB
Tested Applications
WB
Protein ID
116241262
Physical Properties
Liquid

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