ATF4 Antibody

• Background :

  This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2) . The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromsome at q28 in a region containing a large inverted duplication.

• NCBI Gene ID :

  468

• Swiss Prot :

  P18848

• Accession Number :

  P18848

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This ATF4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 171-198 amino acids from the Central region of human ATF4.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Other

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  39 kDa

• Fragment :

  Rabbit Ig

• Applications Notes :

  For WB starting dilution is: 1:1000

• Symbol :

  ATF4

• NCBI Official Name :

  Cyclic AMP-dependent transcription factor ATF-4

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Dey, S., et al. J. Biol. Chem. 285 (43) :33165-33174 (2010)

• Background Reference 02 :

  Frank, C.L., et al. J. Biol. Chem. 285 (43) :33324-33337 (2010)

• Background Reference 03 :

  Rzymski, T., et al. Oncogene 29 (31) :4424-4435 (2010)

• Background Reference 04 :

  Liew, C.W., et al. J. Clin. Invest. 120 (8) :2876-2888 (2010)

• Other Product Names :

  Cyclic AMP-dependent transcription factor ATF-4, cAMP-dependent transcription factor ATF-4, Activating transcription factor 4, Cyclic AMP-responsive element-binding protein 2, CREB-2, cAMP-responsive element-binding protein 2, DNA-binding protein TAXREB67, Tax-responsive enhancer element-binding protein 67, TaxREB67, ATF4, CREB2, TXREB

• Tested Applications :

  WB

• Protein ID :

  116241262

• Physical Properties :

  Liquid