ATF2 Antibody

• Background:

  This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. It forms a homodimer or a heterodimer with c-Jun and stimulates CRE-dependent transcription. This protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. The encoded protein may also be involved in cell's DNA damage response independent of its role in transcriptional regulation. Several alternatively spliced transcript variants have been found for this gene

• NCBI Gene ID:

  1386

• Swiss Prot:

  P15336

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human ATF2 (NP_001871.2) .

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Primary Antibodies

• Field of Research:

  Immunology, Innate Immunity, Signal Transduction, Transcription

• Purification:

  Affinity purification

• Positive Control:

  Lovo

• Concentration:

  Batch dependent

• Buffer:

  PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

• Modification:

  None

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  Store at -20˚ C. Avoid freeze / thaw cycles.

• Calculated Molecular Weight:

  Observed: 70kDa

• Fragment:

  IgG

• Symbol:

  ATF2

• Positive Control 2:

  MCF7

• Positive Control 3:

  SW480

• Positive Control 4:

  K-562

• NCBI Official Name:

  Activating transcription factor 2

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  ATF2, HB16, CREB2, TREB7, CREB-2, CRE-BP1

• Tested Applications:

  WB, IHC, IF

• Physical Properties:

  Liquid