Products for Research Use Only
RegisterLogin

RBL2 Antibody

CAT: 0223-56-286Size: 400 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0223-56-286Size:400 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
RBL2 is a key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. RBL2 may act as a tumor suppressor.
NCBI Gene ID
5934
Swiss Prot
Q08999
Accession Number
Q08999
Host
Rabbit
Reactivity
Human
Immunogen
This RBL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 165-194 amino acids from the N-terminal region of human RBL2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Homology
Predicted species reactivity based on immunogen sequence: Mouse, Rat
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
128 kDa
Fragment
Rabbit Ig
Symbol
RBL2
NCBI Official Name
Retinoblastoma-like protein 2
NCBI Organism
Homo sapiens
Background Reference 01
Schaffer, B.E., et al. Cancer Res. 70 (10) :3877-3883 (2010)
Background Reference 02
Barrow-Laing, L., et al. Virology 400 (2) :233-239 (2010)
Background Reference 03
Lu, F., et al. J. Virol. 84 (6) :2697-2706 (2010)
Background Reference 04
Jowett, J.B., et al. Diabetes 59 (3) :726-732 (2010)
Other Product Names
Retinoblastoma-like protein 2, 130 kDa retinoblastoma-associated protein, p130, Retinoblastoma-related protein 2, RBR-2, pRb2, RBL2, RB2
Tested Applications
WB, Flow
Protein ID
116242746
Physical Properties
Liquid

Related Products

CatalogName
60-514RBL1 Antibody
31-334RBL1 Antibody
64-160WAS Antibody
60-596WAS Antibody
13-349WAS Antibody
62-828Neprilysin Antibody
61-580CAPZB Antibody
55-580HCG_2024410 Antibody
30-580ACPT Antibody
19-580FABP3 Antibody

Alternative Products

CatalogName
70R-33427RBL2 antibody

Popular Products