RBL2 Antibody

• Background :

  RBL2 is a key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. RBL2 may act as a tumor suppressor.

• NCBI Gene ID :

  5934

• Swiss Prot :

  Q08999

• Accession Number :

  Q08999

• Host :

  Rabbit

• Reactivity :

  Human

• Immunogen :

  This RBL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 165-194 amino acids from the N-terminal region of human RBL2.

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Type :

  Primary Antibodies

• Field of Research :

  Cancer, Cell Cycle

• Purification :

  This antibody is purified through a protein A column, followed by peptide affinity purification.

• Concentration :

  Batch dependent

• Homology :

  Predicted species reactivity based on immunogen sequence: Mouse, Rat

• Buffer :

  Supplied in PBS with 0.09% (W/V) sodium azide.

• Modification :

  None

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

• Calculated Molecular Weight :

  128 kDa

• Fragment :

  Rabbit Ig

• Symbol :

  RBL2

• NCBI Official Name :

  Retinoblastoma-like protein 2

• NCBI Organism :

  Homo sapiens

• Background Reference 01 :

  Schaffer, B.E., et al. Cancer Res. 70 (10) :3877-3883 (2010)

• Background Reference 02 :

  Barrow-Laing, L., et al. Virology 400 (2) :233-239 (2010)

• Background Reference 03 :

  Lu, F., et al. J. Virol. 84 (6) :2697-2706 (2010)

• Background Reference 04 :

  Jowett, J.B., et al. Diabetes 59 (3) :726-732 (2010)

• Other Product Names :

  Retinoblastoma-like protein 2, 130 kDa retinoblastoma-associated protein, p130, Retinoblastoma-related protein 2, RBR-2, pRb2, RBL2, RB2

• Tested Applications :

  WB, Flow

• Protein ID :

  116242746

• Physical Properties :

  Liquid